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KMID : 0374019920150020123
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Ewha Medical Journal
1992 Volume.15 No. 2 p.123 ~ p.138
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An Experimental Study of the Effect of Radiation and Cis-dichlorodiammineplatinum(Ⅱ) on the Rat Kidney
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Abstract
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The effect of radiation and cis-dichlorodiammineplatinum(II)(Cis-DDP) in combination was studied in the renal histopathologic changes of the rat. The histologic evaluation was performed 30 days after the single dose of Cis-DDP(2.5mg/kg) and X-ray
irradiation(6. 8. 10 Gy. Single dose) and combination of Cis-DDP and X-ray. For the combined treatment. a single dose of Cis-DDP was given 30 min before or immediately after radiation(pre-and post-radiation group).
Cis-DDP alone. Showed mild necrosis. Degeneration. hemorrhage and focal inflammatory cell infiltrations in the renal tubule and mild congestion of the glomerulus. In radiation alone. Edema of the glomerulus and tubular degeneration was seen with
10
Gy
and 8 Gy. Respectively. With combined chemotherapy and radiation. Edema of glomeruli and tubular degeneration was seen with 8 and 6Gy irradiation. Respectively in both pre-and post-radiation group. Tubular necrosis and degeneration and
interstitial
inflammatory cell infiltrations were more marked in pre-radiation group. When the edema of glomerulus was used as an endpoint. The enhancement ratio was 1.25 in normal rat kidney.
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